The Role of Vesicles in Transporting of Cholera Toxin

The review reports on the secretion pathways of main virulence factor Vibrio cholerae , cholera toxin, both through two-stage Sec-dependent type 2 system and with help vesicles outer membrane V. cholerae. ways toxin transfer into host organism, depending its form, are discussed. well-studied free soluble is secreted extracellularly transmitted in a GM1-dependent manner cholesterolrich lipid rafts. associated has advantages over because substances inside protected from external proteases antibodies by that forms vesicle. Vesicular transporting target cell occurs via clathrin-dependent, caveolin-dependent raft-dependent endocytosis. specific transport route determined structure vesicles. Clathrindependent endocytosis described for strains cultivated at low osmolarity medium, whose contain subunit A inside. Lipid characteristic which located surface. In addition, structures known as caveolae presented.